Quotes from David Quammen

If we can't predict a forthcoming influenza pandemic or any other newly emergent virus, we can at least be vigilant; we can be well-prepared and quick to respond; we can be ingenious and scientifically sophisticated in the forms of our response.

One of the most important problems in epidemiology is to ascertain whether this termination occurs only when no susceptible individuals are left, or whether the interplay of the various factors of infectivity, recovery and mortality, may result in termination, whilst many susceptible individuals are still present in the unaffected population.

So much for where as well as when. AIDS began with a spillover from one chimp to one human, in southeastern Cameroon, no later than 1908 (give or take a margin of error), and grew slowly but inexorably from there.

Laboratory virologists are not generally knockabout people. You don't meet them in bars, waving their arms and bragging lustily about the perils of their métier. They tend to be focused, neat, and still, like nuclear engineers.

Never mind the recovered and immune members of the population; they just represented padding and interference so far as disease propagation was concerned. Continuation of the outbreak depended on the likelihood of encounters between people who were infectious and people who could be infected.

Saying no to the inevitable is one of the few precious ways our own species redeems itself from oblivion- or at least tries to.

ideas—and where facts were scarce, directive questions. Other

The order Chiroptera (the "hand-wing" creatures) encompasses 1,116 species, which amounts to 25 percent of all the recognized species of mammals. To say again: One in every four species of mammal is a bat. Such

SIR model, representing a flow of individuals, during the course of an outbreak, through those three classes I mentioned earlier: from susceptible (S) to infected (I) to recovered (R). Anderson

know that walking into a small woodlot," he wrote, "is riskier than walking into a nearby large, extensive forest.

Most bacteriologists were trained as medical men—Burnet himself had been, before going into bacteriological research—and "their interest in general biological problems was very limited." They cared about curing and preventing diseases, which was well and good; less so about pondering infection as a biological phenomenon, a relationship between creatures, equal in fundamental importance to such other relationships as predation, competition, and decomposition.

Drama Series's carcass was unceremoniously carted away, by the usual contract hauler, to the dump where dead Brisbane horses routinely go. Her cause of death remained uncertain. Had she been bitten by a snake? Had she eaten some poisonous weeds out in that scrubby, derelict meadow? Those hypotheses crumbled abruptly, thirteen days later, when her stable mates began falling ill. They went down like dominoes. This wasn't snakebite or toxic fodder. It was something contagious

His report described a typical beka initiation, complete with slaughtered sheep and chickens, the neck of a tortoise (because it resembles a penis), and "virgin lasses" in attendance through a long prelude that culminates at four in the morning.

The ribosome did not contain the recipe for the protein; it was a tape reader. It could make any protein so long as it was fed the right tape of "messenger" RNA.

Es de suponer que, cuando llegue la próxima gran pandemia, es probable que se conforme a ese mismo y perverso patrón, el de la elevada infectividad antes de los síntomas notables, que la ayudará a moverse entre ciudades y aeropuertos como un ángel de la muerte.

At dawn the boy bathes, then stays awake until late afternoon, pacing and expectant, at which point the circumciser comes at him with a homemade knife. "I nursed my wound for 45 days after," one initiate said.

A plate of Ebola virions mixed with Hendra virions would resemble capellini in a light sauce of capers.

it may cause. Useful as they are to a virus, though, the spikes also represent points of vulnerability. They are the primary targets of immune response by an infected host. Antibodies, produced by white blood cells, are molecules that glom onto the spikes and prevent a virion from grabbing a cell.

What was causing this mayhem? How was it spreading from one horse to another, or anyway getting into so many of them simultaneously? One possibility was a toxic contaminant in the feed supply. Or maybe poison, maliciously introduced. Alternatively, Reid began wondering whether there might be an exotic virus at work, such as the one responsible for African horse sickness (AHS), a disease carried by biting midges in sub-Saharan Africa.

not just Machupo but also Marburg (1967), Lassa (1969), Ebola (1976, with Karl Johnson again prominently involved), HIV-1 (inferred in 1981, first isolated in 1983), HIV-2 (1986), Sin Nombre (1993), Hendra (1994), avian flu (1997), Nipah (1998), West Nile (1999), SARS (2003), and the much feared but anticlimactic swine flu of 2009.

equatorial Africa? Could it have arrived there in one soaring leap, leaving no traces in between? From southwestern Sudan to Manila is almost seven thousand miles as the bat flies. But no bat can fly that far without roosting. Are ebolaviruses more broadly distributed than we suspect? Should scientists start looking for them in India, Thailand, and Vietnam? Or did Reston virus get to the Philippines the same way Taï Forest virus got to Switzerland and Johannesburg—by airplane? If

the good news about Reston virus, derived both from the 1989 US scare and from retrospective research on Luzon, is that it doesn't seem to cause illness in humans, only in monkeys. The bad news is that no one understands why. Apart

sheets, carefully taped together, forming a triptych

Why Big Fierce Animals Are Rare.