Quotes About LTP

Moderate, transient stress (i.e., the good, stimulatory stress) promotes hippocampal LTP, while prolonged stress disrupts it and promotes LTD—one reason why cognition tanks at such times. This is the inverted-U concept of stress writ synaptic.4

Moreover, sustained stress and glucocorticoid exposure enhance LTP and suppress LTD in the amygdala, boosting fear conditioning, and suppress LTP in the frontal cortex. Combining these effects—more excitable synapses in the amygdala, fewer ones in the frontal cortex—helps explain stress-induced impulsivity and poor emotional regulation.