Quotes About Glucocorticoids

This was based on studies of a rare disorder, congenital adrenal hyperplasia (CAH). An enzyme in the adrenal glands has a mutation, and instead of making glucocorticoids, they make testosterone and other androgens, starting during fetal life.

Moreover, sustained stress and glucocorticoid exposure enhance LTP and suppress LTD in the amygdala, boosting fear conditioning, and suppress LTP in the frontal cortex. Combining these effects—more excitable synapses in the amygdala, fewer ones in the frontal cortex—helps explain stress-induced impulsivity and poor emotional regulation.

testosterone increases the excitability of amygdaloid neurons, and glucocorticoids decrease excitability of prefrontal cortical neurons.