Quotes About Ribosomes

I wanted to reveal how genetic code is translated into protein. I knew a great application could be for antibiotics, since half of the useful ones target the ribosomes, but I didn't believe I could contribute to it. It was like the next Mount Everest to conquer. It was my dream to contribute something to humanity.

I used ribosomes from very, very robust bacteria under very, very active conditions and found a way - I actually took advantage of research done before me at the Weizmann, the same institute I am now - how to preserve their activity and their integrity while they crystallized.

Ribosomes contain RNA, messenger RNA provides the information, transfer RNAs brings the amino acids; so the protein-making machinery is an RNA machinery, completely.

Many ribosomes act simultaneously along the mRNA, forming superstructures called polysomes.

I started working on ribosomes when I was a post doc, in 1978, when it would have been impossible, really, to solve it. But, it was just a fundamental problem in biology.

Ribosomes have an error rate of about one letter in 10,000, far lower than the defect rate in our own high-quality manufacturing processes. And they operate at a rate of about 10 amino acids per second, building whole proteins with chains comprising hundreds of amino acids in less than a minute.

Well, the human genome has massive redundancy - that means that two per cent of the DNA does all the work of instructing the ribosomes that build the proteins that make up the cells of your body. Ninety-eight per cent of your DNA just sits there doing nothing. Taking up space in the gene.