Quotes About Phages

It may be hard to imagine a world before antibiotics, but now we must imagine a world where antibiotics are not the only weapon we use against bacteria. And now, ninety years after Herelle first encountered bacteriophages, these viruses may finally be ready to become a part of modern medicine.

The easiest of these viruses to study are the ones that attack bacteria, and they were dubbed (remember the term, for it will reappear when we discuss the discovery of CRISPR) "phages," which was short for "bacteriophages," meaning bacteria-eaters.

phages," which was short for "bacteriophages," meaning bacteria-eaters.

Prior to their discovery in 1917, phages had been linked to miracle waters—rivers in India and other places with the power to cure diseases from leprosy to cholera. Only later did scientists, examining a naturally occurring treatment for dysentery, discover these "cures" were phages, feasting on and eradicating the disease-causing bacteria.

If a sample of soil is diluted, mixed with bacteria, and spread on agar, the phages will dot the culture with plaques after 24 hours of incubation. These plaques may be initiated by more than one phage, and the students engage in further rounds of isolation and bacterial infection to ensure that they have purified single phages. After many more steps in this lengthy procedure, the students purify and sequence the phage DNA, and can submit their sequences to an online database.