Quotes from Robert M. Sapolsky

We process emotionally salient information more rapidly and automatically, but with less accuracy. Frontal function—working memory, impulse control, executive decision making, risk assessment, and task shifting—is impaired, and the frontal cortex has less control over the amygdala. And we become less empathic and prosocial. Reducing sustained stress is a win-win for us and those stuck around us.

Over the course of minutes to hours, hormonal effects are predominantly contingent and facilitative. Hormones don't determine, command, cause, or invent behaviors. Instead they make us more sensitive to the social triggers of emotionally laden behaviors and exaggerate our preexisting tendencies in those domains.

What helps define a particular culture? Values, beliefs, attributions, ideologies.

Como Sullivan e seus colegas escreveram, "o apego [de tal filhote] por quem cuida dele evoluiu para garantir que o filhote estabeleça uma ligação com o cuidador, independente da qualidade dos cuidados recebidos". Em uma tempestade, qualquer mãe serve.

Interestingly, traumatic stress early in life (abuse, for example) greatly increases the risk of IBS in adulthood. This implies that childhood trauma can leave an echo of vulnerability, a large intestine that is hyperreactive to stress, long afterward.

In other words, dopamine is not about the happiness of reward. It's about the happiness of pursuit of reward that has a decent chance of occurring.*

What Wilkinson and others have shown is that poverty is not only a predictor of poor health but, independent of absolute income, so is poverty amid plenty—the more income inequality there is in a society, the worse the health and mortality rates.

Moreover, sustained stress and glucocorticoid exposure enhance LTP and suppress LTD in the amygdala, boosting fear conditioning, and suppress LTP in the frontal cortex. Combining these effects—more excitable synapses in the amygdala, fewer ones in the frontal cortex—helps explain stress-induced impulsivity and poor emotional regulation.

This addition produces a two-by-two matrix: parenting is authoritative (high demand, high responsiveness), authoritarian (high demand, low responsiveness), permissive (low demand, high responsiveness), or neglectful (low demand, low responsiveness).

testosterone increases the excitability of amygdaloid neurons, and glucocorticoids decrease excitability of prefrontal cortical neurons.

All but the most heroically strong among us would slip another step lower in the face of this loss. It is true that hope, no matter how irrational, can sustain us in the darkest of times. But nothing can break us more effectively than hope given and then taken away capriciously. Manipulating these psychological variables is a powerful but double-edged sword.

the opposite of love is not hate, it's indifference.

when women are ovulating, their fusiform face areas respond more to faces, with the ("emotional") vmPFCs responding more to men's faces in particular.

This explains context-dependent craving in addiction.93 Suppose an alcoholic has been clean and sober for years. Return him to where the alcohol consumption used to occur (e.g., that rundown street corner, that fancy men's club), and those potentiated synapses, those cues that were learned to be associated with alcohol, come roaring back into action, dopamine surges with anticipation, and the craving inundates.

LeDoux and others have shown how auditory information about the tone stimulates BLA neurons. At first, activation of those neurons is irrelevant to the central amygdala (whose neurons are destined to activate following the shock). But with repeated coupling of tone with shock, there is remapping and those BLA neurons acquire the means to activate the central amygdala.fn16

US/THEM-ING TYPICALLY involves inflating the merits of Us concerning core values—we are more correct, wise, moral, and worthy when it comes to knowing what the gods want/running the economy/raising kids/fighting this war. Us-ness also involves inflating the merits of our arbitrary markers, and that can take some work—rationalizing why our food is tastier, our music more moving, our language more logical or poetic.

Here are some words of central importance to this book: aggression, violence, compassion, empathy, sympathy, competition, cooperation, altruism, envy, schadenfreude, spite, forgiveness, reconciliation, revenge, reciprocity, and (why not?) love. Flinging us into definitional quagmires.

Research shows that rejecting an offer is an emotional decision, triggered by anger at a lousy offer and the desire to punish. The

Schultz's group has shown that the magnitude of an anticipatory dopamine rise reflects two variables. First is the size of the anticipated reward. A monkey has learned that a light

Thus, adult behavior produces persistent molecular brain changes in offspring, "programming" them to be likely to replicate that distinctive behavior in adulthood.76

Hormonal responses to various fetal and childhood experiences have epigenetic effects on genes related to the growth factor BDNF, to the vasopressin and oxytocin system, and to estrogen sensitivity. These effects are pertinent to adult cognition, personality, emotionality, and psychiatric health. Childhood abuse, for example, causes epigenetic changes in hundreds of genes in the human hippocampus.

Testosterone makes us more willing to do what it takes to attain and maintain status. And the key point is what it takes. Engineer social circumstances right, and boosting testosterone levels during a challenge would make people compete like crazy to do the most acts of random kindness. In our world riddled with male violence, the problem isn't that testosterone can increase levels of aggression. The problem is the frequency with which we reward aggression.

Why has East Asia provided textbook examples of collectivism?21 The key is how culture is shaped by the way people traditionally made a living, which in turn is shaped by ecology. And in East Asia it's all about rice. Rice, which was domesticated there roughly ten thousand years ago, requires massive amounts of communal work. Not just backbreaking planting and harvesting, which are done in rotation because the entire village is needed to harvest each family's rice.

growing strong from adversity is mostly a luxury for those who are better off.